Treatment Of HIV Infection.
HIV / AIDS
Entavir 0.5 mg tablet is an antiviral drug and belongs to a class of drugs called synthetic nucleoside analogs. It works by blocking the DNA synthesis in hepatitis B virus, a process essential for the virus to grow and multiply. Entavir 0.5 mg tablet thus stops the virus from spreading in the body. It does not prevent the spread of HBV infections to other people.
Entecavir, a guanosine nucleoside analog, is a potent and selective inhibitor of hepatitis B virus replication with around 94% patients continuing to remain HBV DNA undetectable and 80% patients with normalization of liver enzymes at the end of 5 years of continuous entecavir therapy. Entecavir resistance is rare in nucleoside-naïve patients, around 1.2% after 5-6 years of treatment. It is recommended as a first-line treatment for lamivudine-naïve chronic hepatitis B patients.
SALT INFORMATION FOR ENTAVIR
Entavir 0.5 mg tablet is used in the treatment of HIV infection and chronic hepatitis B.
For patients with compensated liver disease due to chronic hepatitis B virus infection, the recommended dose of entecavir in nucleoside treatment-naïve adults and adolescents 16 years of age and older is 0.5 mg once daily whereas in adults and adolescents (at least 16 years of age) with a history of hepatitis B viremia while receiving lamivudine or known lamivudine or telbivudine resistance mutations rtM204I/V with or without rtL180M, rtL80I/V, or rtV173L the dose is 1 mg once-daily.
How it works
Entavir 0.5 mg tablet prevents the multiplication of HIV virus in human cells. Thus stops the HIV virus from producing new viruses.
For adult patients with decompensated liver disease due to chronic hepatitis B virus infection, the recommended dose of entecavir is once daily, and dose adjustment is recommended for patients with creatinine clearance below 50 mL / min, including hemodialysis or continuous non-period Bedridden peritoneal dialysis patients (CAPD). The optimal treatment time for entecavir in patients with chronic hepatitis B virus infection and the relationship between treatment and long-term efficacy such as cirrhosis and hepatocellular carcinoma are unclear.
Common Side Effects
Nausea, rash, allergic reactions, dizziness, hair loss, headache, indigestion, vomiting, fatigue, hepatitis B (virus-infected liver) worsen, lactic acidosis.
Expert advice on ENTAVIR
Do not stop taking entecavir without the doctor's advice.
Entecavir should be taken on an empty stomach. Please follow your doctor's instructions.
Before taking entecavir, please consult your doctor if you are pregnant or planning to become pregnant.
If you are breastfeeding, please consult your doctor before taking entecavir.
Do not drive or operate the machine if you experience dizziness, tiredness or drowsiness after taking entecavir.
Hepatitis B may worsen after taking entecavir and stopping the drug. Liver function tests must be performed after treatment and withdrawal.
If you have an AIDS or HIV (human immunodeficiency virus) infection, talk to your doctor before taking entecavir. Patients with suspected entecavir should be tested for HIV.
Report symptoms of nausea, vomiting and stomach pain to your doctor immediately. This may indicate that the life-threatening side effects of entecavir are called lactic acidosis (excessive lactic acid in the blood). The incidence of lactic acidosis in women is higher, especially if the body weight exceeds the standard.
HIV / AIDS